Arp2 — Aspergillus fumigatus

Summary

AFU5G14000 (Arp2) on chromosome 5 of Aspergillus fumigatus encodes a member of the short-chain dehydrogenase/reductase (SDR) family, an oxidoreductase with cholate 7-alpha-dehydrogenase (NAD+) and versicolorin reductase activities, and is annotated with quinone binding and NAD(P)-binding domain features. The gene is associated with DHN-melanin biosynthesis, pigmentation, melanin anabolism, and L-phenylalanine breakdown, as well as with sterigmatocystin anabolism, fatty acid anabolism, and phagocytosis. Studies of related genes in other species link the SDR family to additional oxidoreductase activities (EC 1.3.1.- and 1.1.-.-), though these are not established for Arp2 itself. The gene is also connected to orthologues in other fungi, including Verticillium dahliae, among others.