ERG4 — Aspergillus fumigatus

Summary

AFU5G14350 (ERG4, erg4A) encodes a protein with a Sterol_reductase_CS domain and ERG24_DHCR-like domain, and has D24-sterol reductase activity, D24(24-1)-sterol reductase activity, D14-sterol reductase activity, and NADP binding (EC 1.3.1.71). It localises to the endoplasmic reticulum membrane. The gene is associated with ergosterol anabolism, filamentous growth of a population of unicellular organisms in response to biotic stimulus, hyphal growth, and cellular response to xenobiotic stimulus. It is linked to hypersensitivity and a wide range of phenotypes including abnormal bipolar budding, decreased endocytosis, abnormal plasma membrane morphology, sterility, decreased cell fusion, absent or decreased pheromone-induced cell cycle arrest, decreased shmoo formation, abnormal cell cycle progression, decreased nutrient uptake, abnormal cell wall morphology, decreased invasive growth, and increased cell death. Related genes in other species are linked to reduced virulence and unaffected pathogenicity.