atrR — Aspergillus fumigatus

Summary

AFU5G14140 (atrR) on chromosome 5 of Aspergillus fumigatus encodes a Zn2Cys6 DNA-binding transcription factor. The gene is associated with positive regulation of patulin anabolism, siderophore anabolism, reductive iron assimilation, sterol anabolism, ergosterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, hypersensitivity, and positive regulation of transcription by RNA polymerase II. Its product localises to the membrane, cytosol and nucleus. Related genes in other species link the family to reduced virulence and pulmonary aspergillosis, though pathogenicity is unaffected in some relatives.