atfB — Aspergillus fumigatus

Summary

AFU5G12960 (atfB) on chromosome 5 of Aspergillus fumigatus encodes a bZIP transcription factor that also functions as a chromatin adaptor with DNA-binding transcription activator activity specific to RNA polymerase II. The gene is associated with the regulation of transcription by RNA polymerase II, including both positive and negative regulation, as well as with reciprocal meiotic recombination, suppression of meiotic recombination, and activation of reciprocal meiotic recombination. It has been linked to cellular responses to heat and hydrogen peroxide, the MAPK cascade, osmotic response, signal transduction, and negative regulation of antisense RNA transcription and adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling. The product localises to the nucleus, chromatin, heterochromatin, and the Atf1-Pcr1 complex. Related genes in other species link the family to ear rot in corn and yellow mold in peanut.