MIP1 — Aspergillus fumigatus

Summary

AFU5G12640 (MIP1, AfMIP1) in Aspergillus fumigatus encodes a DNA-directed DNA polymerase with 3'-5' exonuclease activity and DNA binding capacity, belonging to the DNA-dir_DNA_pol_A_mt family. The product localises to mitochondria and the gamma DNA polymerase complex, and is associated with mtDNA replication. The gene is associated with immune response, inflammatory response, leukocyte activation, IL-17A and IL-22 production, neutrophil migration, phagocytosis, and immune evasion. Phenotypic associations include altered cell cycle progression, increased or decreased mutation frequency, abnormal mitochondrial genome maintenance and morphology, decreased viability, sporulation efficiency, biofilm formation, and pseudohyphal growth, as well as changes in telomere length, UV and gamma ray resistance, and carbon and nitrogen source utilisation. Studies of related genes in other species link the family to mitochondrial genome maintenance and respiratory metabolism.