PP2A — Aspergillus fumigatus

Summary

AFU5G11370 (PP2A, also known as AfPP2A or PPG1) encodes a protein serine/threonine phosphatase of the PPA2-like family, with protein phosphatase activity (EC 3.1.3.16) and metal binding. This gene is associated with the regulation of multiple cellular processes, including protein dephosphorylation, the G1/S transition of the mitotic cell cycle, negative regulation of mitophagy, and regulation of TORC1 signaling. It localizes to the PP2A complex, SIP complex, mitochondrial outer membrane, mitotic spindle pole body, and chromatin. Phenotypic associations link AfPP2A to abnormal cell cycle progression, decreased pheromone sensitivity, increased mitochondrial mutation frequency, decreased apoptosis, and altered mitophagy and pexophagy. The gene is also associated with decreased nutrient utilization, abnormal protein secretion, and reduced ionic stress resistance. Studies of related genes in other species suggest the family may be linked to virulence and acid sensitivity.