PET8 — Aspergillus fumigatus

Summary

AFU5G11850, symbol PET8, on Aspergillus fumigatus chromosome 5 encodes a putative mitochondrial carrier protein (Pet8) belonging to the mitochondrial carrier domain superfamily. The gene product is annotated with multiple transmembrane transporter activities, including S-adenosylmethionine permease, citrate carrier, ferrous iron, glycine, magnesium ion, succinate:fumarate antiporter, L-aspartate, and L-glutamate transport, as well as isopentenyl pyrophosphate transmembrane transport activity. It localises to the mitochondrial inner membrane and is associated with isopentenyl pyrophosphate import, S-adenosylmethionine transport, mitochondrial iron transport, citrate transport, magnesium ion export, glycine import, aspartate and glutamate transport, the malate-aspartate shuttle, and heme and ergosterol biosynthesis. Phenotypically, PET8 is linked to altered respiratory growth, nitrogen source utilisation, cell cycle progression, sporulation, filamentous growth, stress resistance (including oxidative, heat, and metal resistance), vegetative growth rate, competitive fitness, and vacuolar morphology.