MNT1 — Aspergillus fumigatus

Summary

AFU5G10760 (MNT1) in Aspergillus fumigatus encodes a mannosylphosphate transferase with alpha-1,2-mannosyltransferase activity, belonging to the Glyco_trans_15 and nucleotide-diphossugar_trans domain families. The gene is associated with protein O-linked and N-linked glycosylation, N-glycan processing, cell wall mannoprotein anabolism, and fungal-type cell wall organization. It is linked to cell-matrix and cell-cell adhesion, adhesion involved in multi-species biofilm formation, asexual sporulation, conidia formation, cell growth, and mitigation of host defenses. The product localizes to the Golgi membrane, ER membrane, plasmalemma, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence.