niaD — Aspergillus fumigatus

Summary

AFU5G10420 (symbol niaD) on chromosome 5 of Aspergillus fumigatus encodes a nitrate reductase [NADPH] (EC 1.7.1.3), a molybdenum cofactor-binding enzyme with sulfite oxidase, cytochrome-b5 reductase, and NADH dehydrogenase activities. The protein contains mopterin oxidoreductase, cytochrome-b5-like heme/steroid-binding, and FAD-binding domains. This gene is associated with nitrate assimilation, anaerobic respiration, cellular respiration, nitric oxide anabolism, detoxification, metal ion transport, and regeneration. It is also linked to polysaccharide, sulfur, arginine, siderophore, gliotoxin, ergosterol, and thiamin metabolism, as well as protein histidyl modification to diphthamide, mcm5 modification, transposition, and the mitotic cell cycle. The product localizes to the mitochondrial outer membrane, endoplasmic reticulum, and plasmalemma. Studies of related genes in other species link the family to nitrate uptake and molybdenum content.