AUS1 — Aspergillus fumigatus

Summary

AFU5G09460 (AUS1) in Aspergillus fumigatus encodes an ABCG-type pleiotropic drug resistance (PDR) transporter, possessing ATP-binding cassette domains and ATP hydrolase activity. The gene is associated with ATP-coupled transmembrane transporter activity and is linked to steroidogenesis, ergosterol anabolism, carbohydrate metabolism, mating, cell growth, and hypersensitivity. It is also connected to xenobiotic detoxification via transmembrane export across the plasma membrane and response to antibiotics. The product localises to the plasma membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed exit from stationary phase, and altered vacuolar distribution and transport. Related genes in other species link the family to multidrug resistance and cellular export processes, though these functions are not directly established for AUS1 in A. fumigatus.