ATRR — Aspergillus fumigatus

Summary

AFU5G10120 (ATRR) in Aspergillus fumigatus encodes a putative NRPS-like enzyme with multiple domains including thioester reductase, acyl carrier protein, and NAD(P)-binding motifs, and is annotated with L-aminoadipate-semialdehyde dehydrogenase, ketoacyl-ACP synthase, fatty acid synthase, ligase, oxidoreductase, and methyltransferase activities. The gene is associated with siderophore anabolism, reductive iron assimilation, lysine anabolism, sterol and ergosterol biosynthesis, polyketide and toxin anabolism, biofilm formation, hyphal growth, and hypersensitivity. It is also linked to secondary metabolism, alkaloid metabolism, methylation, and homeostasis, with the product localizing to the cytosol. Related genes in other species connect the family to N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity and additional oxidoreductase functions.