RTT109 — Aspergillus fumigatus

Summary

AFU5G09540 (symbol RTT109, preferred name AfRTT109) on chromosome 5 of Aspergillus fumigatus encodes a histone acetyltransferase with histone H3K56 acetyltransferase activity (EC 2.3.1.48). The protein belongs to the Histone_AcTrfase_Rtt109/CBP domain family and is associated with nucleosome assembly, regulation of DNA-templated transcription, DNA damage response, DNA replication, and hypersensitivity. It localizes to the vacuole, chromatin, and nucleus. Studies of related genes in other species link the family to reduced virulence and invasive aspergillosis.