SOD1 — Aspergillus fumigatus

Summary

AFU5G09240 (SOD1) on chromosome 5 of Aspergillus fumigatus encodes a copper/zinc superoxide dismutase, an enzyme with superoxide dismutase activity that binds copper and acts on sulphur-group donors with oxygen as acceptor. The gene is associated with superoxide metabolism, removal of O2-, cell redox homeostasis, and cellular responses to oxidative stress and iron ion starvation. It is linked to copper ion transport, cellular copper and zinc ion homeostasis, protein stabilization, and fungal-type cell wall organization. Associations include oxidative stress response, and phenotypes such as decreased spore germination rate, increased necrotic cell death, abnormal vacuolar distribution, and absent oxidative stress resistance. The encoded protein localizes to the cytoplasm, cytosol, nucleus, extracellular region, and mitochondrial envelope lumen.