CMP1 — Aspergillus fumigatus

Summary

AFU5G09360, also known as CMP1, calA, or CNA1, encodes a serine/threonine-protein phosphatase (EC 3.1.3.16) with calmodulin-dependent and calcium-dependent protein phosphatase activity, as well as ferric iron and zinc binding capabilities. This gene is associated with the calcineurin complex and the DPS complex, and is linked to numerous biological processes including exit from dormancy, developmental induction, regulation of cell morphogenesis and polarization, anisotropic cell growth, and positive regulation of clathrin-mediated endocytosis. CMP1 has been connected to invasive pulmonary aspergillosis in a mouse model. Phenotypic associations include abnormal spore germination, altered budding patterns, increased endocytosis, and changes in cell cycle progression, meiosis, and stress resistance. Studies of related genes in other species link the family to loss of pathogenicity and unaffected pathogenicity.