BD — Aspergillus fumigatus

Summary

AFU5G08950, symbol BD (AfBD), encodes a small GTPase of the Ras-type family with GTP, GDP, CTP and UTP binding activity, GTPase activity, and protein serine/threonine kinase activator activity. This gene is associated with the cAMP/PKA signaling cassette, regulation of cell polarization, axial bud site selection, cell-abiotic substrate adhesion, cytogamy, and positive regulation of the pheromone response MAPK cascade. It is linked to cellular response to glucose stimulus, maintenance of protein location, and upregulation of filamentous growth, phenotypic switching, and protein import into nucleus. Localization evidence connects the product to the plasma membrane, cytoplasm, vacuolar membrane, cell division site, and bud neck. Phenotypic associations include altered vacuolar transport, bipolar budding pattern, redox state, mating type switching, osmotic and oxidative stress resistance, and cell cycle progression. Related genes in other species link it to protein content and oxidative stress response.