MPKC — Aspergillus fumigatus

Summary

AFU5G09100 (symbol MPKC) encodes a mitogen-activated protein kinase (MAPK) with serine/threonine kinase activity, classified as EC 2.7.11.24 (ERK1). The protein contains a MAP kinase conserved signature and a protein kinase domain, and localises to both the cytoplasm and nucleus. In Aspergillus fumigatus, MPKC is associated with the stress-activated MAPK cascade, osmotic response, cell wall polysaccharide anabolism, glycan biosynthesis, glycogen anabolism, siderophore anabolism, reductive iron assimilation, biofilm formation, mitochondrial fission, phagocytosis, and cell cycle modulation. It is also linked to carbohydrate storage, nucleotide-sugar metabolism, nitric oxide storage, and heterotrophy. Associations with germination rate and oxidative stress response have been noted. Related genes in other species link the family to hypervirulence and chestnut blight.