CI-1 — Aspergillus fumigatus

Summary

AFU5G07520 (CI-1) in Aspergillus fumigatus encodes a cytochrome P450 monooxygenase, a heme- and iron-binding oxidoreductase that acts on paired donors with incorporation of molecular oxygen. The gene is associated with the biosynthesis of ergosterol, sterols, melanin, terpenoids, and secondary metabolites including griseofulvin, mycophenolic acid, and cichorine. It is linked to the endoplasmic reticulum membrane. Phenotypic associations include increased fermentative growth, decreased endocytosis, absent micronucleophagy, abnormal telomere length and plasma membrane morphology, absent vacuolar transport, decreased meiosis, abnormal autophagy, decreased shmoo formation, increased budding, absent protein secretion, decreased colony size, increased small molecule transport, G2/M cell cycle arrest, decreased cytokinesis, increased cell death, abnormal cytoskeleton and mitochondrial distribution, decreased nutrient uptake, and decreased vegetative growth. Studies of related genes in other species link the family to acid sensitivity.