SNZ1 — Aspergillus fumigatus

Summary

AFU5G08090 (SNZ1, also known as pyroA) in Aspergillus fumigatus encodes a pyridoxal 5'-phosphate synthase (glutamine hydrolyzing) with amine-lyase activity (EC 4.3.3.6), belonging to the PdxS/SNZ family. This enzyme is associated with pyridoxal phosphate, pyridoxine, and vitamin A biosynthesis, as well as amino acid metabolism and homeostasis. The protein localizes to the cytosol and extracellular space. The gene has been linked to numerous cellular phenotypes, including abnormal cell cycle progression (G1/S phase transition delay, metaphase arrest), increased aneuploidy, altered vegetative and respiratory growth rates, decreased biofilm formation, abnormal cell shape and size, defective mitochondrial genome maintenance, and increased prion formation. Related genes in other species connect the family to oxidative stress response.