SHO1 — Aspergillus fumigatus

Summary

AFU5G08420, designated SHO1, encodes a plasma-membrane protein containing an SH3 domain (Sho1_SH3 family). In Aspergillus fumigatus, SHO1 is associated with the HOG response, osmosensory signaling, and the MAPK cascade, as well as with regulation of actin polymerization, cell wall assembly and biogenesis, hyphal growth, morphogenesis, invasive growth, host invasion, and cellular homeostasis. The gene is linked to numerous phenotypes including absent resistance to osmotic, oxidative, toxin, and alkaline pH stresses; absent biofilm formation and anaerobic growth; decreased cytokinesis, budding, and cell cycle progression; abnormal flocculation, filamentous growth, and bipolar budding; increased adhesion and mating efficiency; and delayed nuclear fusion and pexophagy. Studies of related genes in other species connect the SHO1 family to salt tolerance and oxidative stress response.