pyc — Aspergillus fumigatus

Summary

AFU5G07570 (symbol pyc) in Aspergillus fumigatus on chromosome 5 encodes a putative pyruvate carboxylase, annotated with pyruvate carboxylase, acetyl-CoA carboxylase, urea carboxylase, allophanate hydrolase, biotin carboxylase, ligase, hydrolase, ATP binding and metal binding activities. The gene is associated with gluconeogenesis, malonyl-CoA and fatty acid anabolism, urea breakdown, generation of precursor metabolites and energy, and mitotic nuclear membrane biogenesis. Its product localises to mitochondria, cytoplasm and cytosol. Studies of related genes in other species link the family to pyruvate carboxylase (EC 6.4.1.1), acetyl-CoA carboxylase (EC 6.4.1.2) and urea carboxylase (EC 6.3.4.6) activities.