mdrA — Aspergillus fumigatus

Summary

AFU5G06580 (symbol mdrA) on Aspergillus fumigatus chromosome 5 encodes a transmembrane transporter belonging to the major facilitator superfamily (MFS). The gene is associated with membrane transport and has been linked to both the peroxisome membrane and the plasma membrane. Studies of related genes in other species indicate that the MFS transporter family is associated with traits such as phosphorus concentration, germination rate, and oxidative stress response. Additionally, sequence similarity links the family to pathogenicity-related phenotypes, including ear and stalk rot in maize, and interactions with fungal pathogens like Verticillium dahliae and Fusarium oxysporum.