GYP2 — Aspergillus fumigatus

Summary

AFU5G07440 (AfGYP2) on chromosome 5 encodes a putative GTPase activating protein (GAP) with a Rab-GAP TBC domain and EF-hand domains, and has annotated GAP activity and calcium ion binding. It is associated with calcium signaling, actin cytoskeleton organization, exocytosis, ER-to-Golgi transport, vesicle transport, protein transport, hyphal growth, biofilm formation, spore formation, cell cycle, cell growth, homologous recombination, detoxification, carbohydrate metabolism, sterol and ergosterol anabolism, and homeostasis. The gene product localizes to the Golgi-associated vesicle, site of polarized growth, cell division site, plasmalemma, cytoplasm, cytosol, and nucleus. Associations with oxidative stress response have been recorded, and numerous phenotypes linked to this gene include abnormal intracellular transport, Golgi morphology, endocytosis, actin cytoskeleton, cell shape, budding pattern, chitin deposition, protein secretion, vacuolar transport, autophagy, sporulation, and cell cycle progression.