ELP3 — Aspergillus fumigatus

Summary

AFU5G06140 (AfELP3, ELP3) encodes a tRNA uridine(34) acetyltransferase (EC 2.3.1.311) that is a component of the Elongator holoenzyme complex, containing a radical SAM domain, 4Fe-4S cluster binding and GNAT acetyltransferase domains. The gene is associated with tRNA wobble uridine modification, specifically the mcm5 modification, and with regulation of cytoplasmic translational fidelity, translation, gene expression, growth and hyphal growth. It is linked to cellular amino acid homeostasis and localises to the cytoplasm, cytosol and nucleus. AfELP3 is associated with increased virulence and with invasive pulmonary aspergillosis. The gene family has been connected to reduced virulence in other species through sequence similarity studies. Additional associations include abnormal aneuploidy, decreased polyploidy, delayed pexophagy, abnormal chitin deposition, and altered pheromone sensitivity and production.