SKP1 — Aspergillus fumigatus

Summary

AFU5G06060 (AfSKP1, also known as SKP1) encodes a protein containing SKP1-like and BTB/POZ domains, with molecular functions including cullin family protein binding and glutathione binding. The gene is associated with protein ubiquitination, ubiquitin-dependent proteolysis, regulation of DNA recombination, resolution of meiotic recombination intermediates, mitotic cell cycle, and dephosphorylation. It localizes to the cytoplasm, nucleus, ssDNA-dependent ATP-dependent DNA helicase complex, and RAVE complex. AfSKP1 is linked to oxidative stress response, carbon source utilization, redox state, cell cycle progression through G1/S and G2/M transitions, mitotic metaphase/anaphase transition, chromosome segregation, flocculation, adhesion, shmoo formation, mating efficiency, pseudohyphal growth, sporulation, and meiotic recombination. Studies of related genes in other species connect the SKP1 family to the nuclear SCF complex and SCF-dependent proteasomal ubiquitin-dependent protein breakdown.