ldpA — Aspergillus fumigatus

Summary

AFU5G03980 (symbol ldpA) on Aspergillus fumigatus chromosome 5 encodes a LysM domain-containing protein with chitin-binding activity. The gene product is localised extracellularly and is associated with phagocytosis, immune response, and cell death. It has been linked to invasive pulmonary aspergillosis in a mouse model. Studies of related genes in other species connect the family to plant effector functions and avirulence determinants, as well as to interactions with Arabidopsis thaliana, Nicotiana benthamiana, and Solanum lycopersicum, and to diseases including vascular wilt and white muscardine in Galleria mellonella.