raf1 — Aspergillus fumigatus

Summary

AFU5G04300 (raf1) in Aspergillus fumigatus encodes a WD repeat protein containing a WD40 repeat domain and an MLST8 domain. The gene is associated with a wide range of biological processes, including TOR signaling, regulation of actin cytoskeleton organization, hyphal growth, secretion, and DNA-dependent transcription. It has also been linked to meiotic telomere clustering, RNAi-mediated heterochromatin assembly at centromeres, CENP-A containing chromatin assembly, telomeric silencing, and silent mating-type cassette chromatin silencing. Additionally, raf1 is associated with the regulation of IL-1 production and sensitization. The encoded protein localizes to the nucleus, cytosol, chromatin, and specific complexes such as TORC1 and the CLRC complex, as well as subtelomeric, centric, and mating-type region heterochromatin. Related genes in other species, such as clr8, link the family to heterochromatin assembly.