PAR1 — Aspergillus fumigatus

Summary

AFU5G02570, symbol PAR1 (also known as AfSTK-18, TRA1, TRA2, RTS1), encodes a putative histone acetylase complex subunit Paf400 on Aspergillus fumigatus chromosome 5. The product contains Tra1_central, Tra1_ring, PIK-rel_kinase_FAT, FATC, and PI3/4-kinase catalytic domains, and exhibits histone H2A kinase, protein serine/threonine kinase, and ATP-binding activities. PAR1 is associated with TORC1, TORC2, TIP60 histone acetylase, and ATR-ATRIP complexes, and localises to nucleolar chromatin and the perinuclear cytoplasm. The gene is associated with DNA damage response signalling, double-strand break repair regulation, meiotic checkpoints, TORC2 signalling, and positive regulation of ribosomal protein gene transcription and cytoplasmic translation. Phenotypic associations include decreased cell cycle progression rate, altered autophagy and pexophagy, increased mating-type switching, absent X-ray resistance, abnormal sporulation efficiency, and decreased hypoosmotic stress resistance.