aspf1 — Aspergillus fumigatus

Summary

AFU5G02330 (symbol aspf1) on chromosome 5 of Aspergillus fumigatus encodes a ribonuclease/ribotoxin family protein with rRNA endonuclease activity, RNA nuclease activity, and RNA binding capacity. The product is also annotated for IgE binding and localises extracellularly. The gene is associated with modulation of host innate immune response, inflammatory response, sensitization, and immune response. It is linked to chemokine and peptide anabolism, gliotoxin and ergosterol anabolism, heme anabolism, the TCA cycle, fermentation, reductive iron assimilation, and NO storage. Additional associations include negative regulation of cytoplasmic translation, response to oxidative stress, phagocytosis, and invasive growth. Studies of related genes in other species link the family to a 4.6.1.23 enzyme activity, though this is not established for aspf1 itself.