atrR — Aspergillus fumigatus

Summary

AFU5G02270 (atrR) in Aspergillus fumigatus chromosome 5 encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain, possessing sequence-specific DNA-binding and RNA polymerase II-specific transcription factor activity. The gene is associated with siderophore anabolism, reductive iron assimilation, sterol and ergosterol anabolism, sterol homeostasis, biofilm formation, hyphal growth, hypersensitivity, and positive regulation of transcription. It is linked to membrane localisation. Related genes in other species are associated with reduced virulence and pulmonary aspergillosis.