AUS1 — Aspergillus fumigatus

Summary

AFU5G02260 (AUS1) in Aspergillus fumigatus encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP hydrolase activity and ATP binding. The gene is associated with steroidogenesis, ergosterol anabolism, xenobiotic detoxification via transmembrane export across the plasma membrane, mating, carbohydrate metabolism, hypersensitivity, and cell growth. Its product localises to the plasma membrane and membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, absent cell fusion, decreased cell death rate, delayed exit from stationary phase, increased fermentative growth, and abnormal pseudohyphal growth, among many others. Studies of related genes in other species link the family to traits such as plant height, root length, drought tolerance, and protein content, as well as reduced virulence.