AUS1 — Aspergillus fumigatus

Summary

AFU5G00790 (symbol AUS1, also known as abcF) on Aspergillus fumigatus chromosome 5 encodes an ABC transporter, possessing ATP hydrolase and ATP-binding activities. The gene is associated with steroidogenesis, zearalenone biosynthetic process, response to toxic substances, xenobiotic detoxification via transmembrane export across the plasma membrane, mating, ergosterol anabolism, carbohydrate metabolism, hypersensitivity, and cell growth. The product localizes to the vacuolar membrane, plasmalemma, and membrane. Phenotypic associations include abnormal small molecule transport, decreased vacuolar distribution, increased vacuolar transport, increased sporulation rate, absent cell fusion, decreased cell death rate, delayed exit from G0, increased fermentative growth, premature endocytosis, abnormal replicative and chronological lifespan, and abnormal bipolar budding pattern. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance, and oxidative stress response.