CI-1 — Aspergillus fumigatus

Summary

AFU4G14140 (CI-1, AfCI-1) on Aspergillus fumigatus chromosome 4 encodes a cytochrome P450 monooxygenase, a heme- and iron-binding oxidoreductase that acts on paired donors with incorporation of molecular oxygen. The gene is associated with small molecule biosynthesis, particularly sterol, ergosterol, terpenoid, melanin, and mycotoxin anabolism, as well as toxin anabolism. It is linked to membrane localisation and hypersensitivity. Phenotypic associations include altered cell cycle progression (G2/M phase delay, M phase arrest), decreased cytokinesis, increased cell death, abnormal autophagy and vacuolar transport, reduced endocytosis, absent micronucleophagy, abnormal plasma membrane and cytoskeleton morphology, decreased mating response and shmoo formation, increased budding, decreased colony size, and altered nutrient uptake and small molecule transport. Related genes in other species connect the cytochrome P450 family to ergosterol biosynthesis and various stress responses.