CI-1 — Aspergillus fumigatus

Summary

AFU5G00120 (CI-1, AfCI-1) on Aspergillus fumigatus chromosome 5 encodes a cytochrome P450 oxidoreductase/alkane hydroxylase, a member of the CYP52 fungal family, with monooxygenase activity, heme and iron binding, and oxidoreductase activity acting on paired donors with incorporation of molecular oxygen. The gene is associated with the biosynthesis of small molecules, including melanin, sterols, ergosterol, terpenoids, and antibiotics, and with hypersensitivity. It is linked to membrane localisation and to the protein afumB, which centres on hopane-3-beta. Annotated associations connect CI-1 to numerous cellular processes, including abnormal autophagy, endocytosis, vacuolar transport, cytokinesis, cell cycle progression, and increased cell death, as well as decreased colony size, vegetative growth arrest, and abnormal plasma membrane and mitochondrial morphology. Related genes in other species link the family to potassium concentration and acid sensitivity.