ASC1 — Aspergillus fumigatus

Summary

AFU4G13170 (ASC1, also known as cpcB) on chromosome 4 of Aspergillus fumigatus encodes a G-protein complex beta subunit CpcB, a RACK1-like protein containing WD40 repeats. The product is associated with signaling receptor activator activity, PKC binding, G-alpha protein subunit binding, translation regulator and activator activities, ribosomal small subunit binding, and structural ribosome constituent function. It is linked to the cytosolic small ribosomal subunit, ribosome, and nucleus. ASC1 is associated with regulation of amino acid metabolism, GPCR signaling, cleistothecium development, asexual sporulation, positive regulation of autophagy, and negative regulation of cytoplasmic translation and cell integrity MAPK cascade. The gene has been connected to invasive pulmonary aspergillosis, oxidative stress response, and numerous phenotypes including increased adhesion, abnormal bipolar budding, sterile, and decreased meiosis.