ARP1 — Aspergillus fumigatus

Summary

AFU4G13390 (ARP1, AfARP1) encodes an actin-related protein ArpA, a structural constituent of the cytoskeleton with ATP-binding and hydrolase activity. In Aspergillus fumigatus, this gene is associated with DHN-melanin biosynthesis, pigmentation, sporulation, L-phenylalanine breakdown, and immune evasion. The protein localizes to the actin cytoskeleton, dynactin complex, hyphal tip, and sites of polarized growth. Associations with abnormal lifespan, decreased cell fusion, defective shmoo formation, absent filamentous growth, abnormal septum formation, and altered cell cycle progression have been observed. Studies of related genes in other species link the family to dynactin complex function, mitotic recombination, nuclear transport, and chromosome segregation. The gene is also associated with acid sensitivity and decreased respiratory growth through sequence similarity to related genes in other species.