alp1 — Aspergillus fumigatus

Summary

AFU4G11800 (alp1) on chromosome 4 of Aspergillus fumigatus encodes a subtilisin-like serine-type endopeptidase (EC 3.4.21.63) belonging to the peptidase S8 family, with domains including the S8pro/Inhibitor_I9 and PCSK9_ProteinaseK-like regions. The gene is associated with fibrinogen binding, IgE binding, and protease activity, and its product is secreted extracellularly. It has been linked to biological processes including proteolysis, elastin breakdown, protein breakdown, and ergosterol biosynthesis, as well as to host interaction processes such as symbiont-mediated suppression of host immunoglobulin-mediated immune response and complement activation, immune evasion, sensitization, and phagocytosis. Related genes in other species are linked to alkaline proteinase and EC 3.4.21.-.