cpcA — Aspergillus fumigatus

Summary

AFU4G12470 (symbol cpcA, also known as AfCPC-1 and CPC-1) on Aspergillus fumigatus chromosome 4 encodes a bZIP transcription factor, specifically the BZIP transcription factor CpcA, which possesses DNA-binding and RNA polymerase II-specific transcription factor activity. This gene is associated with the regulation of nitrogen utilization and catabolite activation, cellular amino acid homeostasis, and responses to amino acid starvation. It is linked to siderophore and ornithine anabolism, lysine biosynthesis, amino acid import, translation initiation, and nitric oxide storage. The encoded protein localizes to the nucleus and transcription regulator complex. Notably, cpcA is associated with aspergillosis and pulmonary aspergillosis, with links to infection models in Galleria mellonella and Mus musculus. Studies of related genes in other species connect the family to general amino acid control and stress responses.