VOSA — Aspergillus fumigatus

Summary

AFU4G10860 (VOSA, AfVOSA) on Aspergillus fumigatus chromosome 4 encodes a velvet domain-containing protein. This gene is associated with negative regulation of conidiophore development and sexual sporulation, as well as spore wall assembly, autolysis, mycose biosynthesis, and responses to UV, hydrogen peroxide, and oxidative stress. It is linked to sporogenesis, conidia formation, asexual sporulation, secondary metabolism, cell wall organization, and the TCA cycle. The product localizes to the cytoplasm and nucleus and exhibits identical protein binding. Studies of related genes in other species link the family to reduced virulence and pathogenicity in barley and rice diseases, though these associations are not established for A. fumigatus.