SOD2 — Aspergillus fumigatus

Summary

AFU4G11580 (SOD2) in Aspergillus fumigatus encodes a superoxide dismutase with Mn/Fe-binding domains, classified as EC 1.15.1.1, and is annotated to superoxide dismutase activity, manganese binding, and IgE binding. The gene is associated with removal of O2-, evasion or tolerance of host-produced AOS, hyphal growth, detoxification, autophagy, and processes including glutathione and nucleotide metabolism, calcium signaling, and homologous recombination. It is linked to the mitochondrial lumen, mitochondria, and cytosol. Associations include oxidative stress response and photosynthetic rate, as well as phenotypes such as increased necrotic cell death, abnormal respiratory metabolism, increased hydrostatic pressure and freeze-thaw resistance, decreased radiation resistance, and altered cell cycle progression. Studies of related superoxide dismutase genes in other species link the family to sodium concentration, manganese content, and acid sensitivity.