FBP1 — Aspergillus fumigatus

Summary

AFU4G11310 (FBP1) in Aspergillus fumigatus encodes a fructose-1,6-bisphosphatase, a class-I enzyme (EC 3.1.3.11) with fructose 1,6-bisphosphate 1-phosphatase activity and metal binding. The gene is associated with gluconeogenesis, fructose and sucrose anabolism, and cellular response to glucose starvation. Its product localizes to the cytoplasm, cytosol, and nucleus. FBP1 has been linked to numerous phenotypes, including abnormal colony shape, pseudohyphal growth, and entry into G0 stationary phase; increased hydrostatic pressure resistance and respiratory metabolism; absent anaerobic growth, meiosis, peroxisomal transport, and UV resistance; and altered nutrient uptake, nitrogen source utilization, and chemical compound accumulation. Studies of related genes in other species connect the family to oxidative stress response.