cafA — Aspergillus fumigatus

Summary

AFU4G11250 (cafA, also known as NCE103) on chromosome 4 of Aspergillus fumigatus encodes a carbonic anhydrase with carbonic anhydrase activity and zinc binding. The gene is associated with cellular response to carbon dioxide, one-carbon metabolism, heterotrophy, cellular detoxification, and cellular response to oxidative stress. It is linked to regulation of phenotypic switching and down-regulation by symbiont of host gene-for-gene resistance. The product localises to the cytoplasm, nucleus, and mitochondrial envelope lumen. Associations with numerous phenotypes have been observed, including increased aneuploidy and prion formation, decreased pheromone sensitivity, abnormal cell cycle progression, altered filamentous growth, increased chitin deposition, decreased replicative lifespan, and increased chronological lifespan. Related genes in other species link the carbonic anhydrase family to these diverse cellular processes.