cprA — Aspergillus fumigatus

Summary

AFU4G10100 (symbol cprA) on Aspergillus fumigatus chromosome 4 encodes a FAD-binding domain protein with NADPH-hemoprotein reductase activity (EC 1.6.2.4), also annotated as a methionine synthase reductase and NADPH-iron-sulfur protein oxidoreductase. The gene is associated with homocysteine metabolism, de novo L-methionine biosynthesis, ergosterol and sterol biosynthesis, nitric oxide production, iron-sulfur cluster assembly, and cellular response to oxidative stress and detoxification. It is linked to hypersensitivity and localizes to the endoplasmic reticulum membrane, mitochondrial outer membrane, plasma membrane, and cytosol. Related genes in other species, including Fusarium and Verticillium, are linked to sulfite reductase flavoprotein function, though these associations are not established for A. fumigatus.