ppoA — Aspergillus fumigatus

Summary

AFU4G10770 (symbol ppoA) on chromosome 4 of Aspergillus fumigatus encodes a protein with Ppo-like_N, oxylipin biosynthesis, haem peroxidase, and cytochrome P450 domains. The enzyme possesses linoleate 8R-lipoxygenase, 9,12-octadecadienoate 8-hydroperoxide 8S-isomerase, fatty acid peroxidase, dioxygenase, isomerase, monooxygenase, peroxidase and oxidoreductase activities, binds iron and heme, and is classified as EC 1.13.11.60 and EC 5.4.4.5. The gene is associated with oxylipin and prostaglandin biosynthesis, positive regulation of asexual sporulation and conidiophore development, negative regulation of sexual sporulation, hyphal growth, response to oxidative stress, hydrogen peroxide catabolism, and metabolism of long-chain fatty acids, carboxylic acids, glucans, penicillin and sterigmatocystin. It has also been linked to aspergillosis and studied in Mus musculus. Related genes include ppoB and ppoC.