horA — Aspergillus fumigatus

Summary

AFU4G09810 (horA, also known as COQ11 or AfCOQ11) in Aspergillus fumigatus encodes an NAD-dependent epimerase/dehydratase domain-containing protein with protein complex binding activity. This gene is associated with ubiquinone anabolism, CoA biosynthesis, cellular respiration, and homeostasis, and its product localises to the mitochondrial lumen and mitochondria. Associations with pulmonary aspergillosis have been noted. The gene is linked to numerous phenotypes including altered mitochondrial genome maintenance, respiratory metabolism, vegetative growth, biofilm formation, cell cycle progression, telomere length, and mitophagy. Studies of related genes in other species connect the family to coenzyme Q biosynthesis (COQ4, COQ5, COQ8, COQ10) and respiratory growth.