RIC8 — Aspergillus fumigatus

Summary

AFU4G08820 (symbol RIC8, also known as ricA) on Aspergillus fumigatus chromosome 4 encodes RicA, a guanine nucleotide exchange factor containing a Ric8-type domain and an ARM-type fold. The product binds G-alpha protein subunits and is annotated with GDS activity. RicA is associated with positive regulation of conidium formation, asexual sporulation, sporulation, the GPCR signaling pathway, and secondary metabolism. It localizes to the membrane and cytoplasm. Studies of related genes in other species link the Ric8 family to similar signaling and developmental processes, though these associations are not yet established for A. fumigatus.