plb1 — Aspergillus fumigatus

Summary

AFU4G08720 (symbol plb1) on Aspergillus fumigatus chromosome 4 encodes a protein with a LysoPLipase_cat_dom and belongs to the acyltransferase/lysophospholipase family. It has phospholipase A2 activity and phosphatidylcholine lysophospholipase A1 activity (EC 3.1.1.5). This gene is associated with phosphatidylcholine acyl-chain remodeling, phosphoglyceride catabolism, inflammatory and immune responses, host invasion, amino acid anabolism, and morphogenesis. The encoded product localizes to the periplasm, side of membrane, fungal-type cell wall, extracellular region, endoplasmic reticulum, plasmalemma, and cytosol. Studies of related genes in other species link the family to pathogenicity, though this has not been established for AFU4G08720.