NOP7 — Aspergillus fumigatus

Summary

AFU4G08190 (NOP7) in Aspergillus fumigatus encodes a protein containing a PES domain and a BRCT domain, and is associated with RNA and RNP binding. The gene is linked to the maturation of 5.8S and LSU rRNA from tricistronic transcripts, as well as to nonribosomal peptide, lysine, and secondary metabolite biosynthesis, including fumigaclavine C and fumiquinazoline C anabolism. It has been connected to prenylation, phagocytosis, and oxidative stress response. The product localizes to the nucleoplasm and the preribosome large subunit precursor. Associations with cell cycle progression, including delayed or arrested phases, abnormal cytokinesis, sporulation, and meiosis, have been observed, along with links to decreased growth, altered chronological lifespan, and increased ionic stress resistance. Studies of related genes in other species link the family to the PeBoW complex and protein content.