COX10 — Aspergillus fumigatus

Summary

AFU4G08340 (COX10) in Aspergillus fumigatus encodes a UbiA prenyltransferase family protein with haem O synthase activity (EC 2.5.1.141), associated with heme A anabolism. The product localises to the mitochondrial membrane. This gene is associated with numerous phenotypes, including decreased oxidative phosphorylation and respiratory metabolism, abnormal mitochondrial genome maintenance and transport, increased petite and rho- mutation frequency, and altered cell cycle progression. Associations also include decreased filamentous growth and sporulation, abnormal colony appearance, reduced biofilm formation, and increased resistance to hyperosmotic stress and killer toxin. Carbon and nitrogen source utilisation are affected, with increased nitrogen utilisation but absent or decreased carbon utilisation. Related genes in other species link the family to mitochondrial function.