PIM1 — Aspergillus fumigatus

Summary

AFU4G04740 (AfPIM1) encodes a putative Ran exchange factor Prp20/Pim1, containing an RCC1-like domain and a regulator of chromosome condensation domain, and is annotated with GDS activity. In Aspergillus fumigatus, AfPIM1 is associated with mitotic nuclear membrane organization, regulation of mitotic spindle elongation and assembly, Ran protein signal transduction, nucleus organization, cytokine production, inflammatory response, and cell division. It localizes to chromatin, cytoplasm, and nucleus. Phenotypic associations link AfPIM1 to increased pheromone production, abnormal cell cycle progression through G1/S, delayed mitotic cell cycle, decreased cell death, absent nuclear export, abnormal replicative lifespan and prion inheritance, decreased adhesion, increased nutrient uptake, sterility, increased polyploidy, decreased cell fusion, and absent pheromone sensitivity. Studies of related genes in other species connect the family to oxidative stress response.