PST1 — Aspergillus fumigatus

Summary

AFU4G06820 (PST1, also known as ECM33) on chromosome 4 of Aspergillus fumigatus encodes a protein containing leucine-rich repeat and cell wall integrity assembly regulator domains. The gene is associated with ascospore wall biogenesis, pigmentation, phagocytosis, cell-cell adhesion, interaction with host, intracellular signal transduction, cell wall organization, sporulation, and hyphal growth. It localizes to the ascospore wall, external side of the plasma membrane, fungal-type cell wall, and cytoplasm. Associations include abnormal budding, cytokinesis, cell cycle progression, increased flocculation and chitin deposition, decreased mating efficiency and acquired thermotolerance, and altered prion inheritance, protein transport, and redox state. Studies of related genes in other species link the family to reduced virulence and disseminated candidiasis.